Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis.
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چکیده
منابع مشابه
Trifluorothymidine versus adenine arabinoside in the treatment of herpes simplex keratitis.
Trifluorothymidine (TFT) and adenine arabinoside (ara-A) are effective antiviral drugs with a very low toxicity for the cornea. In our study no difference between these 2 drugs in antiviral activity was noted. The average healing time for TFT was 11-14 days and for ara-A 10-54 days. These data differ markedly from those of other studies. This was the result of the use of additional criteria for...
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In previous studies adenine arabinoside and trifluorothymidine were found to be equally effective treatments for dendritic ulcers of the cornea, but a trend emerged which suggested that in amoeboid ulcers trifluorothymidine was more effective. The collection of additional cases confirms the superiority of trifluorothymidine in such cases.
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Adenine arabinoside (Ara-A) and Ara-A monosphosphate (Ara-AMP) ointments were able to prevent the fatal outcome of herpes simplex virus (HSV)-induced skin infection of the lumbosacral area in hairless mice. Ara-A and Ara-AMP had no irritating effect on the skin, but in a number of animals a protracted healing time of the skin lesions after the treatment was observed. The compounds conferred onl...
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Recent work has shown that the new antiviral acyclovir (acycloguanasine) is a highly effective antiviral drug against the herpes simplex virus."2 It acts mainly on virally infected cells by blocking viral particle formation before the particles pass through the nuclear membrane3 by means of inhibiting viral DNA polymerase after being converted by virally specific thymidine kinase.4 In tissue cu...
متن کاملCryogenic Treatment of Herpes Simplex Keratitis.
DURING the early stage of our experiments on the use of low temperature for cataract extraction (Krwawicz, 1961, 1963), we had several opportunities of observing the effects of accidentally touching the cornea with the cryoextractor refrigerated to about -79°C. This accident proved to be quite harmless in all cases as no lasting effect on the clarity of the cornea could be seen after the tissue...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1980
ISSN: 0007-1161
DOI: 10.1136/bjo.64.1.33